This application is a division of application Ser. No. 09/869,432, filed Aug. 21, 2001, now U.S. Pat. No. 6,891,527. U.S. application Ser. No. 09/869,423 is a national phase entry of PCT/GB2000/004635, filed Dec. 5, 2000, which claims priority to GB 9928682.5 filed Dec. 6, 1999.